Another proof that COVID is a multi-system cluster bomb

Another proof that COVID is a multi-system cluster bomb

IF further evidence was needed that SARS-CoV-2 infection has long-term consequences for the human body, research led by Monash University has provided it, highlighting the need for GPs and other frontline doctors to be aware of their patients’ COVID 19 history .

The research, led by epidemiologist and PhD candidate Stacey Rowe, and co-authored by Victoria’s Chief Health Officer Professor Brett Sutton and renowned infectious disease epidemiologist Professor Allen Cheng, among others, he announced SERVANT.

“Essentially what we wanted to do was see what types of hospitalizations might have been associated with getting COVID-19 — whether, for example, it caused complications other than respiratory,” Ms Rowe said. InSight+.

Rowe and colleagues analyzed population-wide surveillance and administrative data for all laboratory-confirmed cases of COVID-19 reported to the Victorian Department of Health from 23 January 2020 to 31 May 2021 – before the introduction of the vaccine and the emergence of the Omicron variant – and associated data on hospital admissions (admission dates up to 30 September 2021).

“A total of 20,594 cases of COVID-19 were reported, and 2,992 people (14.5%) were hospitalized with COVID-19,” Rowe and colleagues reported in SERVANT.

“Incidence of hospitalization within 89 days of the onset of COVID-19 illness was higher than during the baseline period for several conditions, including myocarditis and pericarditis (IRR, 14.8; 95% CI, 3.2–68.3), thrombocytopenia (IRR , 7.4; 95% CI, 4.4-12.5), pulmonary embolism (IRR, 6.4; 95% CI, 3.6-11.4), acute myocardial infarction (IRR, 3.9; 95% CI, 2.6-5.8) and cerebral infarction (IRR, 2.3; 95). % CI, 1.4–3.9).”

In other words, says Ms Rowe, “there are significant risks associated with SARS-CoV-2 infection” beyond the initial illness of COVID-19.

“You are 15 times more likely to get myocarditis requiring hospitalization after COVID-19 compared to before,” she said.

“Things like a heart attack or an acute myocardial infarction happen very shortly before getting a COVID infection, but other conditions like clotting conditions – pulmonary embolism, for example – that risk was highest later in the course of the illness from COVID, the highest between 14 and on the 60th day after the COVID disease.”

Other results were also telling.

“The rate of hospitalization for cerebral infarction was twice as high after the onset of COVID-19 as during the initial period,” wrote Rowe and colleagues. “Other investigators (here, here and here) estimated that the risk of stroke is 2 to 13 times higher for people with COVID-19.”

Professor Cheng, talk to InSight+said that as testing and tracking of positive COVID-19 cases was now optional in Australia, it was more difficult to know exactly who had COVID.

“What this study suggests is that [the possibility of a previous COVID illness] should be on the radar, because there is a window of increased risk,” he said.

“If someone develops, say, chest pain, within a few months of having COVID, we really have to be careful about that, because the pain is probably less likely to represent a myocardial infarction than in other cases.

“You can’t say that every heart attack that happens after COVID is caused by COVID. But there is a period of increased risk and it seems to be close to when you will get COVID.”

Rowe and colleagues recommend vaccination and “other mitigation strategies.”

“Our findings point to the need for ongoing measures to mitigate COVID-19, including vaccination, and support early diagnosis and treatment of complications in people with a history of SARS-CoV-2 infection,” they wrote.

“The pathophysiological mechanisms underlying the persistence of symptoms and the development of major complications remain to be elucidated, the prevalence of post-COVID-19 conditions (according to vaccination status) and the risks of post-vaccination complications to be quantified.”

Professor Cheng said InSight+:

“What [this study] it shows that you better not get COVID and whatever you do is probably a good thing.

“Vaccination is the simplest way to protect yourself from getting COVID, but it’s not perfect. Not going out when there’s a lot of COVID out there, wearing masks, improving ventilation and all those other things are also important.”

At one point in SERVANT the authors of the article wrote:

“Some complications of COVID-19 clinically resemble those reported after vaccination against SARS-CoV-2, which is important when evaluating alleged adverse reactions after vaccination. Furthermore, we found that the incidence of hospitalization with severe cardiac and thromboembolic events after SARS-CoV-2 infection is greater than the reported risk of these events after vaccination.”

said Mrs. Rowe InSight+:

“What we found with this study, and what other international studies have found, is that the risk of myocarditis is higher after SARS-CoV-2 infection than after vaccination.

“While people [who feel they have been injured by the vaccine] could catch it, there are now many studies showing that the risk is higher after infection than after vaccination.”

Professor Cheng agreed.

“It’s important to recognize that people do have side effects after vaccination – myocarditis happens, often after the second dose, usually within a day,” he said. “It is very unequivocal because of the vaccination.

“But the question from a public health point of view is whether the benefits outweigh the risks. COVID itself can cause myocarditis at a higher rate [than vaccination]. And that means it’s still better to get vaccinated.”

Ms Rowe said the study showed that COVID-19 was not a simple respiratory disease.

“These findings really show that COVID-19 is a multi-organ disease, not a respiratory infection. If more research can be focused on understanding these pathophysiological mechanisms, then we can begin to think about how we can best prevent them.”

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